| pubmed-article:6456451 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6456451 | lifeskim:mentions | umls-concept:C0007090 | lld:lifeskim |
| pubmed-article:6456451 | lifeskim:mentions | umls-concept:C0014653 | lld:lifeskim |
| pubmed-article:6456451 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:6456451 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:6456451 | lifeskim:mentions | umls-concept:C0003236 | lld:lifeskim |
| pubmed-article:6456451 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:6456451 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:6456451 | pubmed:dateCreated | 1981-11-18 | lld:pubmed |
| pubmed-article:6456451 | pubmed:abstractText | The equilibrium binding of the carcinogens N-hydroxy-N-acetyl-2-amino-fluorene (HAAF) and 4-nitroquinoline-1-oxide (NQO) to phi X174RF DNA have been studied by phase partition techniques. Both molecules bind in a cooperative manner with only a few carcinogen molecules binding to each phi X174RF DNA molecule. The binding data for both HAAF and NQO fit a model in which two carcinogens cluster into a small number of sites--four sites for HAAF and twelve sites for NQO. Phase partition techniques were also used to study the binding of actinomycin D to both calf thymus DNA and poly (dG-dC) . poly (dG-dC) at much lower r values than had been previously reported. These data exhibit humped Scatchard plots which are indicative of cooperative binding; the overall shape of the Scatchard plots are consistent with a model for drug induced allosteric transitions in the DNA structure. The cooperativity in the actinomycin D binding to calf thymus DNA increases with decreasing sodium chloride concentration, suggesting a role for DNA flexibility in allosteric binding. | lld:pubmed |
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| pubmed-article:6456451 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6456451 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6456451 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6456451 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:6456451 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6456451 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:6456451 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:6456451 | pubmed:author | pubmed-author:WinkleS ASA | lld:pubmed |
| pubmed-article:6456451 | pubmed:author | pubmed-author:KrughT RTR | lld:pubmed |
| pubmed-article:6456451 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6456451 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:6456451 | pubmed:volume | 9 | lld:pubmed |
| pubmed-article:6456451 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6456451 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6456451 | pubmed:pagination | 3175-86 | lld:pubmed |
| pubmed-article:6456451 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6456451 | pubmed:year | 1981 | lld:pubmed |
| pubmed-article:6456451 | pubmed:articleTitle | Equilibrium binding of carcinogens and antitumor antibiotics to DNA: site selectivity, cooperativity, allosterism. | lld:pubmed |
| pubmed-article:6456451 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6456451 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6456451 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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