Linked Life Data

6456062

Source:http://linkedlifedata.com/resource/pubmed/id/6456062

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1981-11-18
pubmed:abstractText
A panel of monoclonal antibodies with well-defined specificities were used as probes to investigate the phenotypes and lineage of circulating lymphoid cells and splenocytes in untreated patients with Hodgkin's disease. A significant relative and absolute reduction in T cells (anti-T3+) was found only in patients with B-symptoms. There was no alteration in the fraction of helper (anti-T4+) or cytotoxic/suppressor (anti-T5+) T cells circulating in peripheral blood when compared to normals, nor was there activation of these cells as measured by the development of surface Ia (anti-I1+). Circulating T cell subsets were not altered 5 to 14 days after splenectomy. Splenic T cells were increased equally in involved and uninvolved spleen when compared with control spleens obtained from accident victims. These findings indicate that abnormal T cell function in Hodgkin's disease may be the result of subtle alterations in T cells or non-T immunoregulatory mechanisms.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0008-543X
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
48
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1170-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Lymphoid subpopulations of peripheral blood and spleen in untreated Hodgkin's disease.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.