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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1981-8-27
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pubmed:abstractText |
T cells responsive to macrophages (M phi) in the autologous mixed lymphocyte reaction (AMLR) contain those cells that can be induced to proliferate by soluble antigens. Negative solution (5-bromo-2-deoxyuridine and light) of T cells activated by autologous M phi also removed those cells required for reactivity to Candida albicans and purified protein derivative. Positive selection of T cells responsive to autologous M phi yields a population that is simultaneously enriched in antigen reactivity. Some patients demonstrating cutaneous anergy and diminished in vitro blast transformation in response to soluble antigen also lack T cells responsive to the AMLR to M phi. When considered in conjunction with previously reported data, these findings indicate the AMLR occurring between T cells and M phi in the absence of soluble antigen represents self recognition occurring between antigen-reactive T cells and antigen-presenting M phi.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-102728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-127826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-131174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-305460,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-307186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-307765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-4542806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-5523578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-58030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-6245140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-63988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-6447724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-6997424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-70497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6453920-73181
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
153
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
476-81
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6453920-Animals,
pubmed-meshheading:6453920-Antibodies,
pubmed-meshheading:6453920-Antibodies, Monoclonal,
pubmed-meshheading:6453920-Antigens,
pubmed-meshheading:6453920-Cattle,
pubmed-meshheading:6453920-Cytotoxicity, Immunologic,
pubmed-meshheading:6453920-Humans,
pubmed-meshheading:6453920-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:6453920-Macrophages,
pubmed-meshheading:6453920-Mice,
pubmed-meshheading:6453920-Rosette Formation,
pubmed-meshheading:6453920-T-Lymphocytes
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pubmed:year |
1981
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pubmed:articleTitle |
Antigen-reactive T cells can be activated buy autologous macrophages in the absence of added antigen.
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pubmed:publicationType |
Journal Article
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