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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
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pubmed:dateCreated |
1985-1-3
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|
pubmed:abstractText |
Pretreatment of cultured human fibroblasts with the calcium ionophore A 23187 resulted in a decrease in low-density lipoprotein internalization. This effect was dose-dependent and did not occur in a medium devoid of calcium. About 2-fold reduction was observed with 10(-5)M A 23187. In contrast, the low-density lipoprotein binding was only slightly affected. The incorporation of [14C]acetate and [14C]oleate into all classes of lipids (sterol, triacylglycerols and phospholipids) was strikingly reduced by ionophore pretreatment.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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|
pubmed:issn |
0014-5793
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
177
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
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pubmed:pagination |
76-80
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6437867-Acetic Acid,
pubmed-meshheading:6437867-Acetic Acids,
pubmed-meshheading:6437867-Calcimycin,
pubmed-meshheading:6437867-Calcium,
pubmed-meshheading:6437867-Cells, Cultured,
pubmed-meshheading:6437867-Dose-Response Relationship, Drug,
pubmed-meshheading:6437867-Female,
pubmed-meshheading:6437867-Fibroblasts,
pubmed-meshheading:6437867-Humans,
pubmed-meshheading:6437867-Lipoproteins, LDL,
pubmed-meshheading:6437867-Lung,
pubmed-meshheading:6437867-Oleic Acid,
pubmed-meshheading:6437867-Oleic Acids,
pubmed-meshheading:6437867-Pregnancy
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pubmed:year |
1984
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pubmed:articleTitle |
Effects of the calcium ionophore A 23187 on low-density lipoprotein processing and lipid metabolism in cultured human fibroblasts.
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pubmed:publicationType |
Journal Article
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