Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1984-7-17
pubmed:abstractText
Amiodarone, an iodine-containing drug used frequently in the treatment of cardiac arrhythmias and angina pectoris, has many effects on thyroid hormone metabolism, including decreasing the production of triiodothyronine (T3) and decreasing the clearance of thyroxine and reverse T3. These effects result in elevated serum thyroxine and reverse T3 concentrations and decreased serum T3 concentrations. In addition, iodine-induced hyperthyroidism or hypothyroidism may occur in patients chronically treated with amiodarone. This study is a retrospective analysis of the incidence of thyroid dysfunction in Lucca and Pisa, West Tuscany, Italy, and in Worcester, Massachusetts. Hyperthyroidism was a more frequent (9.6%) complication of amiodarone therapy in West Tuscany, where iodine intake is moderately low; hypothyroidism was more frequent (22%) in Worcester, where iodine intake is sufficient. In patients receiving chronic amiodarone therapy, clinically suspected hyperthyroidism is best confirmed by showing elevations in serum T3 or free T3 concentrations; hypothyroidism is best diagnosed by showing an elevated serum thyrotrophin concentration. Thyroid function should be carefully monitored in patients receiving amiodarone chronically, especially if they have goiter or Hashimoto's thyroiditis.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0003-4819
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
N
pubmed:pagination
28-34
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:6428291-Adult, pubmed-meshheading:6428291-Aged, pubmed-meshheading:6428291-Amiodarone, pubmed-meshheading:6428291-Benzofurans, pubmed-meshheading:6428291-Female, pubmed-meshheading:6428291-Goiter, pubmed-meshheading:6428291-Heart Diseases, pubmed-meshheading:6428291-Humans, pubmed-meshheading:6428291-Hyperthyroidism, pubmed-meshheading:6428291-Hypothyroidism, pubmed-meshheading:6428291-Iodine, pubmed-meshheading:6428291-Italy, pubmed-meshheading:6428291-Long-Term Care, pubmed-meshheading:6428291-Male, pubmed-meshheading:6428291-Massachusetts, pubmed-meshheading:6428291-Middle Aged, pubmed-meshheading:6428291-Retrospective Studies, pubmed-meshheading:6428291-Thyroglobulin, pubmed-meshheading:6428291-Thyroid Diseases, pubmed-meshheading:6428291-Thyroxine, pubmed-meshheading:6428291-Triiodothyronine, pubmed-meshheading:6428291-Triiodothyronine, Reverse
pubmed:year
1984
pubmed:articleTitle
Environmental iodine intake and thyroid dysfunction during chronic amiodarone therapy.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't