| pubmed-article:6420707 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6420707 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:6420707 | lifeskim:mentions | umls-concept:C0301872 | lld:lifeskim |
| pubmed-article:6420707 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:6420707 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:6420707 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:6420707 | pubmed:issue | 5949 | lld:pubmed |
| pubmed-article:6420707 | pubmed:dateCreated | 1984-3-2 | lld:pubmed |
| pubmed-article:6420707 | pubmed:abstractText | T lymphocytes produce a variety of immunoregulatory molecules including gamma interferon (IFN-gamma) and antigen-specific suppressor and enhancer factors. During our studies of active substances obtained from cloned T-cell lines, we observed that certain fractions administered to mice resulted in enhancement of immune responses. Preliminary characterization of the substance suggested that it could be IFN-gamma and we therefore undertook a study of the action of IFN-gamma produced by recombinant DNA methodology on immune responses. We found that for several antigens, administration of IFN-gamma to mice leads to two- to five-fold enhancement of antibody formation provided that the IFN-gamma and antigen are administered together. The effect was dose dependent, giving a maximal response at 500-600 anti-viral units per mouse. Preliminary studies suggest that the macrophage may be the target of IFN-gamma action. Addition of IFN-gamma to cultures of a macrophage cell line leads to a greater than 10-fold increase in the level of RNA coding for I-region-encoded cell surface molecules. | lld:pubmed |
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| pubmed-article:6420707 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6420707 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6420707 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6420707 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6420707 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:6420707 | pubmed:author | pubmed-author:NakamuraMM | lld:pubmed |
| pubmed-article:6420707 | pubmed:author | pubmed-author:GefterM LML | lld:pubmed |
| pubmed-article:6420707 | pubmed:author | pubmed-author:DaleyM JMJ | lld:pubmed |
| pubmed-article:6420707 | pubmed:author | pubmed-author:PearsonG DGD | lld:pubmed |
| pubmed-article:6420707 | pubmed:author | pubmed-author:ManserTT | lld:pubmed |
| pubmed-article:6420707 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6420707 | pubmed:volume | 307 | lld:pubmed |
| pubmed-article:6420707 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6420707 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6420707 | pubmed:pagination | 381-2 | lld:pubmed |
| pubmed-article:6420707 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:6420707 | pubmed:meshHeading | pubmed-meshheading:6420707-... | lld:pubmed |
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| pubmed-article:6420707 | pubmed:meshHeading | pubmed-meshheading:6420707-... | lld:pubmed |
| pubmed-article:6420707 | pubmed:articleTitle | Effect of IFN-gamma on the immune response in vivo and on gene expression in vitro. | lld:pubmed |
| pubmed-article:6420707 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6420707 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6420707 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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