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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1984-1-27
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pubmed:abstractText |
Steady-state gas exchange was studied in anesthetized paralyzed dogs subjected to high-frequency ventilation (HFV) to determine the effects of oscillation frequency (f 10-40 Hz) and stroke volume (Vs 20-40 ml) on gas exchange efficiency. Alveolar gas fractions were measured by rapid withdrawal of lung gas while oscillations and the bias flow circuit were interrupted. Alveolar ventilation (VA) calculated from steady-state CO2 elimination and FACO2 was found to exhibit a frequency-dependent maximum. Similarly, PaCO2 increased and PaO2 decreased again when f exceeded a critical level. VA was 13% of total ventilation (f . Vs) at 10 Hz (40 ml Vs) decreasing to about 4% at 40 Hz. Blood - gas differences for O2 (PA - Pa) were about 6 torr and close to zero for CO2 (Pa - PA). Lung volume assessed from He wash-out was increased with f and Vs. O2 uptake and CO2 elimination were significantly enhanced by HFV as a function of Vs. Because the effective VT was essentially unknown, the apparent gas exchange inefficiency at high f and Vs values may be due to the functional characteristics of the apparatus rather than a general feature of HFV.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0034-5687
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-17
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pubmed:dateRevised |
2009-11-11
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pubmed:meshHeading |
pubmed-meshheading:6417747-Animals,
pubmed-meshheading:6417747-Arteries,
pubmed-meshheading:6417747-Carbon Dioxide,
pubmed-meshheading:6417747-Dogs,
pubmed-meshheading:6417747-Lung Volume Measurements,
pubmed-meshheading:6417747-Oxygen,
pubmed-meshheading:6417747-Oxygen Consumption,
pubmed-meshheading:6417747-Partial Pressure,
pubmed-meshheading:6417747-Pulmonary Gas Exchange,
pubmed-meshheading:6417747-Respiration,
pubmed-meshheading:6417747-Stroke Volume,
pubmed-meshheading:6417747-Tidal Volume,
pubmed-meshheading:6417747-Time Factors,
pubmed-meshheading:6417747-Ventilators, Mechanical
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pubmed:year |
1983
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pubmed:articleTitle |
Pulmonary gas exchange during high-frequency ventilation in dogs.
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pubmed:publicationType |
Journal Article
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