|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
22
|
|
pubmed:dateCreated |
1984-1-7
|
|
pubmed:abstractText |
We have studied somatic cell hybrids between mouse myeloma cells and IARC-BL2 Burkitt lymphoma human cells carrying a t(8;22) chromosome translocation for the presence and expression of human immunoglobin lambda chains and for the c-myc oncogene. The results indicate that the c-myc oncogene remains on the 8q+ chromosome and that the excluded and rearranged C lambda allele translocates from chromosome 22 to this chromosome 8. As a result of the translocation, transcriptional activation of the c-myc oncogene on the rearranged chromosome 8 (8q+) occurs, while the c-myc oncogene in the normal chromosome 8 is transcriptionally silent. These findings suggest that the translocation of a rearranged immunoglobulin locus to the 3' side of an unrearranged c-myc oncogene may enhance its transcription and contribute to malignant transformation.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-114999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-14168277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-189310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-4113130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-467575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6188153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6246372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6271555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6287464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6304538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6308654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6401867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6402758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6402776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6754388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6795508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6801764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6805411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6812058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6813863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6818551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6961453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-6961456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-7260888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-946170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6417658-9732746
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0027-8424
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
80
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6922-6
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:6417658-Burkitt Lymphoma,
pubmed-meshheading:6417658-Cell Line,
pubmed-meshheading:6417658-Chromosome Banding,
pubmed-meshheading:6417658-Chromosomes, Human, 21-22 and Y,
pubmed-meshheading:6417658-Chromosomes, Human, 6-12 and X,
pubmed-meshheading:6417658-Humans,
pubmed-meshheading:6417658-Immunoglobulin lambda-Chains,
pubmed-meshheading:6417658-Karyotyping,
pubmed-meshheading:6417658-Nucleic Acid Hybridization,
pubmed-meshheading:6417658-Oncogenes,
pubmed-meshheading:6417658-Transcription, Genetic,
pubmed-meshheading:6417658-Translocation, Genetic
|
|
pubmed:year |
1983
|
|
pubmed:articleTitle |
Transcriptional activation of an unrearranged and untranslocated c-myc oncogene by translocation of a C lambda locus in Burkitt.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
