Linked Life Data

6405514

Source:http://linkedlifedata.com/resource/pubmed/id/6405514

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-6-17
pubmed:abstractText
Treatment with the immunoregulatory fungus metabolite cyclosporin A exacerbated the course of Trypanosoma cruzi infection in outbred as well as in inbred BALB/c mice. This effect was not observed in congenitally athymic, nu/nu, mice but was readily reproduced in their thymus-bearing, nu/+, littermates. These results suggest that the deleterious action of cyclosporin A on the course of experimental Chagas' disease results from activity of the drug on thymus or thymus-derived lymphocytes and emphasizes the role of T cells in host defense against T. cruzi infection.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0303-4208
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4-6
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Exacerbation of Trypanosoma cruzi infection in mice treated with the immunoregulatory agent cyclosporin A.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.