Linked Life Data

6403491

Source:http://linkedlifedata.com/resource/pubmed/id/6403491

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1983-5-5
pubmed:abstractText
It has been reported that left lower lobe pulmonary blood flow (Q) and alveolar CO2 decrease then oscillate in a progressively damped manner when the lobar inspirate is changed from pure O2 to N2. This damped oscillatory response of lobar Q is abolished by maintaining lobar CO2 constant. We set out to develop the simplest mathematical model that can simulate these experimental results by using techniques derived from control theory. Different models were tested. The simplest model that predicts the experimental data incorporates an exponential decrease of lobar Q to local alveolar hypoxia (time constant 3 min) and a damped oscillatory response of lobar Q to local alveolar hypocapnia. The response to hypocapnia has two components: a vasodilator effect possibly related to intracellular [H+] and a vasoconstrictor effect possibly related to changes of molar CO2. Both these components (time constants of 4.8 min) interact with each other by cross-coupled elements (time constants of 4.8 min). This model can be used to forecast results so that its validity can be tested by experiment.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0161-7567
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
445-52
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Dynamic response of local pulmonary blood flow to alveolar gas tensions: analysis.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't