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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1985-4-26
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pubmed:abstractText |
The influence of dietary modification of polyunsaturated fatty acids (PUFA) on renin secretion, renal vascular tone and prostanoid excretion was studied in isolated perfused rat kidneys under basal conditions and in response to angiotensin II. After a four-week regimen of diets enriched with safflower oil, linseed oil or saturated fat, providing 20% of total energy intake (20 energy %), the animals which were fed linseed oil showed a significant fall in the proportion of arachidonic acid in renal phospholipids and a reduction in urinary prostaglandin excretion. In comparison with the other dietary groups, linseed oil feeding also resulted in a consistently lower renal vascular tone with increasing doses of angiotensin II. Under basal conditions both the PUFA-fed groups had significantly lower renal venous renin secretion rates relative to the saturated fat-fed control group. Infusion of angiotensin II (10 ng/min) suppressed renin secretion and abolished significant differences between the groups. As both the control group and the safflower oil group excreted similar levels of urinary prostaglandins, these results suggest that dietary enrichment with 20 energy % PUFA alters renin secretion by a prostaglandin-independent mechanism and that this may contribute to the lower blood pressures observed in these animals compared with the saturated fat-fed control group.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/6-Ketoprostaglandin F1 alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprost,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprostone,
http://linkedlifedata.com/resource/pubmed/chemical/Fatty Acids, Unsaturated,
http://linkedlifedata.com/resource/pubmed/chemical/Linoleic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Linolenic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Phospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins E,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandins F,
http://linkedlifedata.com/resource/pubmed/chemical/Renin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0263-6352
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
265-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6397528-6-Ketoprostaglandin F1 alpha,
pubmed-meshheading:6397528-Angiotensin II,
pubmed-meshheading:6397528-Animals,
pubmed-meshheading:6397528-Dietary Fats,
pubmed-meshheading:6397528-Dinoprost,
pubmed-meshheading:6397528-Dinoprostone,
pubmed-meshheading:6397528-Fatty Acids, Unsaturated,
pubmed-meshheading:6397528-Kidney,
pubmed-meshheading:6397528-Linoleic Acids,
pubmed-meshheading:6397528-Linolenic Acids,
pubmed-meshheading:6397528-Male,
pubmed-meshheading:6397528-Perfusion,
pubmed-meshheading:6397528-Phospholipids,
pubmed-meshheading:6397528-Prostaglandins E,
pubmed-meshheading:6397528-Prostaglandins F,
pubmed-meshheading:6397528-Rats,
pubmed-meshheading:6397528-Rats, Inbred Strains,
pubmed-meshheading:6397528-Renin,
pubmed-meshheading:6397528-Vascular Resistance
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pubmed:year |
1984
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pubmed:articleTitle |
An inhibitory effect of dietary polyunsaturated fatty acids on renin secretion in the isolated perfused rat kidney.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
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