Linked Life Data

6391987

Source:http://linkedlifedata.com/resource/pubmed/id/6391987

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1985-2-21
pubmed:abstractText
Adipocyte insulin binding and insulin sensitivity to stimulation of lipogenesis were assessed in a group of extremely 'brittle' diabetic patients who were resistant to subcutaneous insulin therapy and had required frequent and prolonged hospital admission. These patients had significantly lower maximum adipocyte insulin binding (1.78 +/- 0.18%) than age-, sex- and weight-matched stable diabetic control subjects (2.57 +/- 0.36%; p less than 0.05). Scatchard analysis suggested that the decreased binding was secondary to reduced receptor affinity with no change in receptor number. Adipocytes from the brittle subjects displayed resistance to insulin stimulation of lipogenesis compared with those from diabetic or normal control groups (half-maximal stimulation at 34 +/- 4, 15 +/- 3 and 13 +/- 2 pmol/l respectively; p less than 0.01 between brittle and stable diabetic groups). In the one subject who was treated with intraperitoneal insulin, the changes in insulin binding and sensitivity were found to have reverted towards normal. The peripheral tissue abnormalities of brittle diabetes may exacerbate the clinical syndrome although the relationship of these changes to the primary cause of the syndrome is uncertain.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0012-186X
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
441-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Adipocyte insulin binding and insulin sensitivity in 'brittle' diabetes.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't