Linked Life Data

6389784

Source:http://linkedlifedata.com/resource/pubmed/id/6389784

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1985-1-15
pubmed:abstractText
Spectrin is a major skeletal component of the erythrocyte membrane and is essential in controlling cell shape and structural stability. The brain has also been found to be rich in an immunoreactive and structural analogue of spectrin. In the present study, spectrin was localized in the mouse brain by indirect immunofluorescence using an antibody to erythrocyte spectrin that cross-reacts specifically with the alpha and beta subunits of brain spectrin. Spectrin antigens were concentrated in neuronal perikarya and cell processes. Synaptic structures and axons were observed to have little detectable spectrin antigen by immunofluorescence methodology. The cell bodies of glia had a less intense immunoreactivity in contrast to neurons, and glial processes and myelin were unstained. Cell nuclei of neural cells were not fluorescent. These results show that (a) spectrin is found in all regions of mammalian brain and its intensity corresponds to neural cell density, (b) different neural cell types contain variable spectrin content, and (c) within a single neural cell, the regional disposition of spectrin varies.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0270-6474
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3089-100
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Localization of spectrin in mammalian brain.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't