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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
1984-5-14
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pubmed:abstractText |
Trypanosoma musculi-induced immunosuppression was examined in both congenitally athymic (nude) mice and their phenotypically normal, euthymic littermates using T-independent (polyvinylpyrrolidone = PVP) and T-dependent (sheep erythrocyte = SE) antigens. T. musculi-infected nude mice had significantly diminished direct (IgM) plaque-forming cell (PFC) responses to PVP. In euthymic mice, T. musculi parasitemia significantly inhibited the direct PFC response to both PVP and SE. Trypanosoma musculi-infected euthymic mice had significantly diminished indirect (IgG) SE-specific PFC responses if priming occurred during parasitemia; however, T. musculi parasitemia did not significantly decrease indirect SE-specific PFC responses in euthymic mice if the mice were primed before infection.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-3395
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
823-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6368787-Animals,
pubmed-meshheading:6368787-Antigens, T-Independent,
pubmed-meshheading:6368787-Hemolytic Plaque Technique,
pubmed-meshheading:6368787-Immune Tolerance,
pubmed-meshheading:6368787-Immunization,
pubmed-meshheading:6368787-Immunoglobulin G,
pubmed-meshheading:6368787-Immunoglobulin M,
pubmed-meshheading:6368787-Immunologic Memory,
pubmed-meshheading:6368787-Mice,
pubmed-meshheading:6368787-Mice, Nude,
pubmed-meshheading:6368787-Povidone,
pubmed-meshheading:6368787-T-Lymphocytes,
pubmed-meshheading:6368787-Time Factors,
pubmed-meshheading:6368787-Trypanosomiasis
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pubmed:year |
1983
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pubmed:articleTitle |
Immunosuppression in mouse trypanosomiasis: inhibition of secondary antibody responses is dependent on the time of antigen priming.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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