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pubmed:otherAbstract |
PIP: The data in the literature on clinical and experimental studies of cardiovascular disorders caused by hormonal contraception are reviewed. The review indicates that even small doses of estrogens and progesterone increase the volume of circulating blood. Estrogen/gestagen preparations cause increased serum levels of low-density lipoproteins and, therefore, can contribute to the development of cardiovascular diseases. From these data, it is concluded that hormonal contraceptives should not be given to women with lipid metabolism disorders. Risk analysis shows that short-term (less than 12-18 months) use of contraceptive estrogens and gestagens produces only insignificant and reversible changes in the cardiovascular system. High risks of arterial hypertension, thromboembolism, and myocardial infarction are caused by uncontrolled, long-term use of pills containing high gestagen doses (over 50 ug).
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