|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
1984-2-24
|
|
pubmed:abstractText |
The in vivo activity of thymopentin in guinea pigs was assessed electromyographically 18 h after intravenous or subcutaneous injections or infusions ranging over varying periods of time. The lowest threshold dose required to establish a positive effect was obtained with a 30-60 min i.v. infusion (0.38-0.75 micrograms/kg) and we found that we needed X 5 times this dose with 30 min s.c. infusion, X 10 this dose with 10 min i.v. or s.c. infusion, X 200 this dose with bolus IV injection and X 400 this dose with bolus s.c. injection. The marked increase of potency of thymopentin with infusion should be considered in designing clinical regimens.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0367-8377
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
22
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
568-72
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6360927-Animals,
pubmed-meshheading:6360927-Dose-Response Relationship, Drug,
pubmed-meshheading:6360927-Female,
pubmed-meshheading:6360927-Guinea Pigs,
pubmed-meshheading:6360927-Hormones,
pubmed-meshheading:6360927-Infusions, Parenteral,
pubmed-meshheading:6360927-Injections, Intravenous,
pubmed-meshheading:6360927-Injections, Subcutaneous,
pubmed-meshheading:6360927-Male,
pubmed-meshheading:6360927-Neuromuscular Junction,
pubmed-meshheading:6360927-Peptide Fragments,
pubmed-meshheading:6360927-Thymopentin,
pubmed-meshheading:6360927-Thymopoietins,
pubmed-meshheading:6360927-Thymus Hormones
|
|
pubmed:year |
1983
|
|
pubmed:articleTitle |
Thymopentin (TP-5) potency in vivo is enhanced by slow infusion.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
