Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1984-2-24
pubmed:abstractText
The anti-tumor activity of endotoxin (LPS), derived from E. coli O127, on the subcutaneous tumor MH134 inoculated into C3H/He mice in vivo was examined. On repeated examination, LPS administration of 50-100 micrograms/head induced a 50% complete cure rate. However, pretreatment with K76COONa inhibited the anti-tumor activity of LPS, and no case of cure could be found. These results showed that the main anti-tumor activity of LPS administration consisted of complementary activation, mainly from the C5 step. The fact that the intraperitoneal administration of human complement activated serum with agar apparently inhibited the tumor growth in vivo certified these phenomena.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0435-1339
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
436-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Anti-tumor activity of endotoxin depends on activation of serum complement fragments.
pubmed:publicationType
Journal Article, Comparative Study