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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
|
pubmed:dateCreated |
1983-12-17
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pubmed:abstractText |
Seventeen patients were treated with high-dose melphalan with autologous bone marrow transplant (ABMT) and cyclophosphamide pretreatment. All of the patients had marrow reconstitution. Although there was one death caused by infection, high-dose melphalan with ABMT causes toxicity that is generally acceptable, and can achieve a high-response rate, but with responses of short duration in tumors resistant to standard-dose combination chemotherapy. In other poor-prognosis tumors that are sensitive to chemotherapy, or can be debulked surgically, or locally irradiated, high-dose melphalan with ABMT given as late intensification therapy may significantly prolong time to relapse, and ultimately prolong survival.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
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pubmed:issn |
0008-543X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
15
|
pubmed:volume |
52
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1783-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6354413-Adult,
pubmed-meshheading:6354413-Bacterial Infections,
pubmed-meshheading:6354413-Bone Marrow Transplantation,
pubmed-meshheading:6354413-Combined Modality Therapy,
pubmed-meshheading:6354413-Cyclophosphamide,
pubmed-meshheading:6354413-Female,
pubmed-meshheading:6354413-Humans,
pubmed-meshheading:6354413-Male,
pubmed-meshheading:6354413-Melphalan,
pubmed-meshheading:6354413-Middle Aged,
pubmed-meshheading:6354413-Myeloproliferative Disorders,
pubmed-meshheading:6354413-Neoplasms,
pubmed-meshheading:6354413-Prognosis,
pubmed-meshheading:6354413-Vomiting
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pubmed:year |
1983
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pubmed:articleTitle |
High-dose melphalan with autologous bone marrow transplant. Treatment of poor prognosis tumors.
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|