|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003241,
umls-concept:C0004358,
umls-concept:C0025914,
umls-concept:C0026809,
umls-concept:C0033268,
umls-concept:C0175668,
umls-concept:C0205263,
umls-concept:C0851285,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
1983-10-8
|
|
pubmed:abstractText |
A/J mice were found to produce autoreactive IgM anti-IgG1 in response to secondary immunization with a number of protein antigens. No anti-IgG1 was produced after a single such immunization, indicating that antigen: IgG1 antibody complexes were responsible for inducing the autoreactive response. The size of the anti-IgG1 response was in some cases massive and of the same order of magnitude as the response to the foreign immunizing material. No significant anti-IgG2a, anti-IgG2b, or anti-IgG3 response was found in mice producing anti-IgG1. Virtually all of the anti-IgG1 material produced was of the IgM class and bound to the Fc region of autologous IgG1. A component of the anti-IgG1 was shown to be able to distinguish between the two mouse IgG1 allotypes. These results suggest that self-reactive anti-IgG is a common component of the secondary immune response of mice that may have powerful physiological and immunoregulatory effects.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-13358793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-13755149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-13778623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-13859099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-13974644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-14000921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-14007218,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-14087624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-14215782,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-301174,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-307690,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-312900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-326444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-376732,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-4110016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-4403474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-4542309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-4930072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-5316191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-5653817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-5676924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-59692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-6109170,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-6161873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-6165587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-6179088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-6767242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-6967092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-6970221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-6976413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-7025211,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-7054355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-7077223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-714156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-7350249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350525-81235
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0022-1007
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
158
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
529-45
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:6350525-Animals,
pubmed-meshheading:6350525-Antibody Specificity,
pubmed-meshheading:6350525-Antibody-Producing Cells,
pubmed-meshheading:6350525-Autoimmune Diseases,
pubmed-meshheading:6350525-Binding Sites, Antibody,
pubmed-meshheading:6350525-Haptens,
pubmed-meshheading:6350525-Hemolytic Plaque Technique,
pubmed-meshheading:6350525-Immunization, Secondary,
pubmed-meshheading:6350525-Immunoglobulin Allotypes,
pubmed-meshheading:6350525-Immunoglobulin G,
pubmed-meshheading:6350525-Immunoglobulin M,
pubmed-meshheading:6350525-Mice,
pubmed-meshheading:6350525-Mice, Inbred A,
pubmed-meshheading:6350525-Mice, Inbred BALB C,
pubmed-meshheading:6350525-Mice, Inbred C57BL,
pubmed-meshheading:6350525-Rheumatoid Factor
|
|
pubmed:year |
1983
|
|
pubmed:articleTitle |
Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|
