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rdf:type |
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lifeskim:mentions |
umls-concept:C0009498,
umls-concept:C0011155,
umls-concept:C0024109,
umls-concept:C0026809,
umls-concept:C0038172,
umls-concept:C0205439,
umls-concept:C0221099,
umls-concept:C0439660,
umls-concept:C0449432,
umls-concept:C1179435,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1705248,
umls-concept:C1880266
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pubmed:issue |
3
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pubmed:dateCreated |
1983-10-21
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pubmed:abstractText |
Mice of the C5-deficient DBA/2J and B10.D2/oSnJ inbred strains were aerosolized with Staphylococcus aureus, and the pulmonary clearance of bacteria was determined 4 h later. Both C5-deficient strains had a significantly decreased lung clearance of S. aureus compared with their genetically closest C5-sufficient relatives, DBA/1J and B10.D2/nSnJ strains, respectively. Serum hemolytic activity and pulmonary clearance of S. aureus were also investigated in F1 and F2 progenies (DBA/1J X DBA/2J and DBA/2J X B10.D2/oSnJ). Serum hemolytic activity was present in all F1 (DBA/1J X DBA/2J) mice, and their pulmonary clearance of S. aureus was no different from that of the C5-sufficient parents (DBA/1J). The absence of serum hemolytic activity (absence of C5) in all mice from F1 and F2 (DBA/2J X B10.D2/oSnJ) and 20% of the F2 (DBA/1J X DBA/2J) was related to a decreased lung clearance of S. aureus. These results are consistent with an autosomal recessive pattern of heredity for the murine abnormality in pulmonary clearance of S. aureus.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-114074,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-126034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-13974902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-14113111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-14149927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-27534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-284412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-335934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-394641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-4246566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-4258194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-478640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-492335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-4959665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-500215,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-574148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-582028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-6404822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-6766905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-6982230,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-6995480,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-7052569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-7081809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-7086356,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-7095846,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-7227564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-7235362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-7240751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-7380548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-7382721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-7451658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-804439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6350178-9364
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1071-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6350178-Aerosols,
pubmed-meshheading:6350178-Animals,
pubmed-meshheading:6350178-Complement C5,
pubmed-meshheading:6350178-Female,
pubmed-meshheading:6350178-Hemolytic Plaque Technique,
pubmed-meshheading:6350178-Immunologic Deficiency Syndromes,
pubmed-meshheading:6350178-Lung,
pubmed-meshheading:6350178-Male,
pubmed-meshheading:6350178-Mice,
pubmed-meshheading:6350178-Mice, Inbred AKR,
pubmed-meshheading:6350178-Mice, Inbred BALB C,
pubmed-meshheading:6350178-Mice, Inbred DBA,
pubmed-meshheading:6350178-Staphylococcus aureus
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pubmed:year |
1983
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pubmed:articleTitle |
Impaired lung defenses against Staphylococcus aureus in mice with hereditary deficiency of the fifth component of complement.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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