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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-9-9
pubmed:abstractText
Lung innervation has been studied in the past by methylene blue staining and silver impregnation and more recently by histochemical methods. These techniques give only a partial picture of the total innervation. We have delineated the innervation of the lung in man and three other mammalian species by immunostaining with antibodies to two new markers of nervous tissue. These markers are neurone-specific enolase (NSE), an enzyme present in nerve cells in both the central and the peripheral nervous systems, and S-100, a protein found in glial cells. Throughout the respiratory tract NSE was localised in ganglion cells and nerve fibres in all species examined, while S-100 was found in the supporting glial cells of ganglia and in Schwann cells of peripheral nerves. The distribution of NSE immunoreactivity in serial sections was compared with that of acetylcholinesterase-containing, noradrenergic, and peptide-containing nerves. In all areas NSE was found to be a specific marker for all three types of nerves. Thus these two antibodies provide an effective histological means of examining both the neuronal and the non-neuronal components of the lung innervation and should be of value in investigating this system in lung disease.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-1092636, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-110910, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-1179313, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-1252955, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-13429361, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-14109806, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-14229991, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-14392240, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-31568, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-362800, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-4118860, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-4247101, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-4571769, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-4863647, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-4955975, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-5081, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-511607, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-5445025, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-6032097, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-6104598, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-6162128, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-6180890, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-6250447, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-699378, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-6996580, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-6998654, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-7033363, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-7035961, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-7059833, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-7106520, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-7226189, http://linkedlifedata.com/resource/pubmed/commentcorrection/6348994-7296630
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0040-6376
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
333-40
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:6348994-Humans, pubmed-meshheading:6348994-Animals, pubmed-meshheading:6348994-Adolescent, pubmed-meshheading:6348994-Infant, pubmed-meshheading:6348994-Lung, pubmed-meshheading:6348994-Guinea Pigs, pubmed-meshheading:6348994-Aged, pubmed-meshheading:6348994-Child, pubmed-meshheading:6348994-Rats, pubmed-meshheading:6348994-Peptides, pubmed-meshheading:6348994-Infant, Newborn, pubmed-meshheading:6348994-Neurons, pubmed-meshheading:6348994-Respiratory System, pubmed-meshheading:6348994-Trachea, pubmed-meshheading:6348994-Cats, pubmed-meshheading:6348994-Female, pubmed-meshheading:6348994-Male, pubmed-meshheading:6348994-Norepinephrine, pubmed-meshheading:6348994-Nasal Mucosa, pubmed-meshheading:6348994-Adult, pubmed-meshheading:6348994-Middle Aged, pubmed-meshheading:6348994-Acetylcholinesterase, pubmed-meshheading:6348994-Nerve Tissue Proteins, pubmed-meshheading:6348994-Histocytochemistry, pubmed-meshheading:6348994-Fluorescent Antibody Technique, pubmed-meshheading:6348994-Phosphopyruvate Hydratase, pubmed-meshheading:6348994-Rats, Inbred Strains, pubmed-meshheading:6348994-S100 Proteins, pubmed-meshheading:6348994-Immunoenzyme Techniques
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