Linked Life Data

6347547

Source:http://linkedlifedata.com/resource/pubmed/id/6347547

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-9-9
pubmed:abstractText
The observation that, in rats, metronidazole exhibited antimicrobial activity against resistant Escherichia coli (when this was accompanied by susceptible Bacteroides fragilis) prompted us to attempt to reproduce this phenomenon in another species and under other experimental conditions. In experiment 1, mice injected intraperitoneally with an E. coli/B. fragilis mixture were treated with metronidazole, 250 mg/kg given by mouth at 0 and 10 h, or left untreated. At 24 h, viable counts of bacteria in blood and peritoneal washings were determined. In experiment 2, mice with 5-day-old subcutaneous abscesses containing E. coli and B. fragilis were also either given metronidazole as above or left untreated. At 24 h, viable counts of bacteria in pus were determined. Metronidazole affected neither the frequency with which E. coli persisted at the three sites, nor the viability of E. coli at these sites. This was so despite the fact that, in each of the sites, a significant B. fragilis kill was registered. Thus, pending elucidation of the mechanism by which the phenomenon operates, its non-appearance in these experiments cautions against the extrapolation of the original observations beyond the circumstances under which they were first made.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0009-3157
pubmed:author
pubmed:issnType
Print
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
225-9
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Effect of metronidazole on Escherichia coli in the presence of Bacteroides fragilis: an investigation in mice.
pubmed:publicationType
Journal Article