Linked Life Data

6345406

Source:http://linkedlifedata.com/resource/pubmed/id/6345406

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-8-17
pubmed:abstractText
Intraepithelial lymphocytes have been studied in the small intestinal epithelium of normal and thymus-deficient rats. A method is described that allows recovery of purified intraepithelial lymphocytes with high yield and viability. Granular intraepithelial lymphocytes were present in normal numbers in jejunal sections from nude rats and from adult thymectomized, irradiated, bone marrow-reconstituted rats. These probably corresponded to the cells with prominent cytoplasmic granules seen in smears of isolated intraepithelial lymphocytes. Studies in athymic chimeras indicated that both granular and nongranular intraepithelial cells differentiate from bone marrow without requirement for thymus processing and that they are relatively more radio-resistant than classical lymphocytes. It is suggested that all or most intraepithelial lymphocytes form a single cell lineage in which the degree of cytoplasmic differentiation is controlled by either the thymus or T lymphocytes. Intraepithelial lymphocytes are not postthymic T cells and their relationship to mucosal mast cells and to natural killer cells is discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0020-5915
pubmed:author
pubmed:issnType
Print
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
317-27
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Granular intraepithelial lymphocytes of the rat small intestine. I. Isolation, presence in T lymphocyte-deficient rats and bone marrow origin.
pubmed:publicationType
Journal Article