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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0002191,
umls-concept:C0005456,
umls-concept:C0017906,
umls-concept:C0022663,
umls-concept:C0085697,
umls-concept:C0205214,
umls-concept:C0206243,
umls-concept:C0333562,
umls-concept:C0334135,
umls-concept:C0866126,
umls-concept:C0996858,
umls-concept:C1517945,
umls-concept:C1522240,
umls-concept:C1882365
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pubmed:issue |
1
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pubmed:dateCreated |
1983-5-5
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pubmed:abstractText |
Sclerotic processes of glomeruli in chronic pyelonephritis (CPN) and chronic diffuse proliferative glomerulonephritis (CDPGN) were investigated in a lectin binding study in connection with an immunofluorescent examination of protease inhibitor deposition. Ulex europaeus agglutinin-I (UEA-I), which is specific to a certain terminal alpha-L-fucosyl residue of glycoconjugates, specifically labelled intact endothelia of glomerular capillaries, peritubular capillaries and blood vessels in human kidneys. Segmental or global loss of the UEA-I binding with glomerular capillaries was observed in the sclerotic areas where alpha 1-antitrypsin (alpha 1AT) deposits were always detected in the glomeruli with segmental or global sclerosis of CPN. This high correlation between loss of UEA-I binding and alpha 1AT deposition was also observed in the affected glomeruli of CDPGN. In considering glomerular sclerosis, it is significant that loss of UEA-I binding and alpha 1AT deposition are common to both CPN and CDPGN, although their original etiologies are quite different.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0028-2766
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
38-43
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:6339965-Animals,
pubmed-meshheading:6339965-Fluorescent Antibody Technique,
pubmed-meshheading:6339965-Glomerulonephritis,
pubmed-meshheading:6339965-Humans,
pubmed-meshheading:6339965-Kidney Glomerulus,
pubmed-meshheading:6339965-Lectins,
pubmed-meshheading:6339965-Mice,
pubmed-meshheading:6339965-Protease Inhibitors,
pubmed-meshheading:6339965-Pyelonephritis,
pubmed-meshheading:6339965-alpha 1-Antitrypsin
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pubmed:year |
1983
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pubmed:articleTitle |
Deposition of alpha 1-antitrypsin and loss of glycoconjugate carrying Ulex europaeus agglutinin-I binding sites in the glomerular sclerotic process. Phenomena common to chronic pyelonephritis and chronic diffuse proliferative glomerulonephritis.
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pubmed:publicationType |
Journal Article
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