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rdf:type |
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lifeskim:mentions |
umls-concept:C0010640,
umls-concept:C0014834,
umls-concept:C0069281,
umls-concept:C0439851,
umls-concept:C0741847,
umls-concept:C1523987,
umls-concept:C1552596,
umls-concept:C1552848,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1947931,
umls-concept:C2754469
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pubmed:issue |
1
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pubmed:dateCreated |
1983-2-25
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pubmed:abstractText |
Mutations were found which enable Escherichia coli K-12 to form homocysteine in the absence of cystathionase. The formation of homocysteine in the mutant strains required cystathionine gamma-synthetase, the metB gene product, but bypassed the normal intermediate cystathionine. It is concluded that cystathionine gamma-synthetase catalyzes the formation of homocysteine directly from O-succinylhomoserine and an as-yet-unidentified sulfur donor. The mutation apparently causes the formation of this sulfur donor and has been named metQ. The expression of the metQ gene is under catabolite repression.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6336741-13278318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6336741-13650640,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6336741-13877467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6336741-13893449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6336741-14340600,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6336741-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6336741-16923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6336741-21876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6336741-4280071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6336741-4552408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6336741-4559736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6336741-5340123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6336741-788919
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
153
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
558-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1983
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pubmed:articleTitle |
Direct homocysteine biosynthesis from O-succinylhomoserine in Escherichia coli: an alternate pathway that bypasses cystathionine.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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