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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1985-2-4
|
| pubmed:abstractText |
Using a mouse liver microsomal preparation, it was found that the heterocyclic ring system of MPTP underwent an initial alpha-oxidation to give chemically reactive metabolites that may be associated with the induction of Parkinsonism by MPTP. Subsequent oxidative metabolic transformations of these intermediates were found to give a lactam metabolite and a pyridone metabolite that potentially may interact with the neurotransmitter system.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0006-291X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
14
|
| pubmed:volume |
125
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
484-90
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6335033-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine,
pubmed-meshheading:6335033-Animals,
pubmed-meshheading:6335033-Biotransformation,
pubmed-meshheading:6335033-Kinetics,
pubmed-meshheading:6335033-Male,
pubmed-meshheading:6335033-Mass Spectrometry,
pubmed-meshheading:6335033-Mice,
pubmed-meshheading:6335033-Microsomes, Liver,
pubmed-meshheading:6335033-Pyridines
|
| pubmed:year |
1984
|
| pubmed:articleTitle |
Metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse liver preparations.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|