Linked Life Data

6331485

Source:http://linkedlifedata.com/resource/pubmed/id/6331485

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-9-17
pubmed:abstractText
The serum activities of two lysosomal enzymes, beta-N-acetylglucosaminidase (EC 3.2.1.30; NAG) and beta-glucuronidase (EC 3.2.1.31; GLU) were analysed in 116 male patients with silicosis. Twenty-eight of the patients were matched with controls of similar sex, age and exposure to silica dust but with no radiographical evidence of silicosis. A control group which had not been exposed to silica dust consisted of male blood donors. The mean activity of NAG in serum was higher in the silicosis patients than in the blood donors (P less than 0.01). Similarly, the NAG level in the silicosis patients with matched controls was higher than that in the silica-exposed controls (P less than 0.05). The silicosis patients who showed a progression of small opacities by one or more subcategories had a slightly higher mean NAG activity in their sera than the patients with no progression but this difference did not reach statistical significance; the activity was higher than in silica-exposed controls (P less than 0.05). We suggest that these findings may be related to the effects of silica on macrophages which have been observed experimentally in vitro and in vivo and might indicate an increased turnover of macrophages caused by silica dust and active, progressive silicotic fibrosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0007-0971
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-24
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Serum beta-N-acetylglucosaminidase and beta-glucuronidase activities in silicosis patients and in workers exposed to silica dust.
pubmed:publicationType
Journal Article