Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1984-8-8
pubmed:abstractText
Cellular oncogenes comprise a small family of genes, highly conserved throughout vertebrate evolution, that code for proteins with diverse functions including DNA binding, protein kinase, and cellular growth factor activities. Cellular oncogenes are important in certain aspects of the proliferation and differentiation of normal cells. Under some circumstances these genes may also induce malignant transformation of normal cells. Various mechanisms may underlie their involvement in carcinogenesis. Incorporation of all, or part of, cellular oncogenes into RNA tumor viruses, mutations in gene structure, or translocation of cellular oncogenes from one chromosome to another may all be associated with the induction of malignant change in cells. In some of these situations altered oncogene products are made. Knowledge about the biology of oncogenes may lead to improved techniques for cancer detection and perhaps new approaches to cancer treatment.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0003-4819
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
223-33
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:6331242-Animals, pubmed-meshheading:6331242-Avian myeloblastosis virus, pubmed-meshheading:6331242-Base Sequence, pubmed-meshheading:6331242-Cell Differentiation, pubmed-meshheading:6331242-Cell Division, pubmed-meshheading:6331242-Cell Line, pubmed-meshheading:6331242-Cell Transformation, Neoplastic, pubmed-meshheading:6331242-DNA, Viral, pubmed-meshheading:6331242-DNA-Binding Proteins, pubmed-meshheading:6331242-Growth Substances, pubmed-meshheading:6331242-Humans, pubmed-meshheading:6331242-Neoplasm Proteins, pubmed-meshheading:6331242-Neoplasms, pubmed-meshheading:6331242-Oncogenes, pubmed-meshheading:6331242-Phosphotransferases, pubmed-meshheading:6331242-Protein Biosynthesis, pubmed-meshheading:6331242-Retroviridae, pubmed-meshheading:6331242-Transformation, Genetic, pubmed-meshheading:6331242-Translocation, Genetic, pubmed-meshheading:6331242-Viral Proteins
pubmed:year
1984
pubmed:articleTitle
Oncogenes: implications for the diagnosis and treatment of cancer.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review