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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5967
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pubmed:dateCreated |
1984-7-9
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pubmed:databankReference |
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pubmed:abstractText |
The complete 1,210-amino acid sequence of the human epidermal growth factor (EGF) receptor precursor, deduced from cDNA clones derived from placental and A431 carcinoma cells, reveals close similarity between the entire predicted v-erb-B mRNA oncogene product and the receptor transmembrane and cytoplasmic domains. A single transmembrane region of 23 amino acids separates the extracellular EGF binding and cytoplasmic domains. The receptor gene is amplified and apparently rearranged in A431 cells, generating a truncated 2.8-kilobase mRNA which encodes only the extracellular EGF binding domain.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0028-0836
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
309
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pubmed:owner |
NLM
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pubmed:authorsComplete |
N
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pubmed:pagination |
418-25
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:6328312-Amino Acid Sequence,
pubmed-meshheading:6328312-Base Sequence,
pubmed-meshheading:6328312-Carcinoma, Squamous Cell,
pubmed-meshheading:6328312-Cell Line,
pubmed-meshheading:6328312-DNA,
pubmed-meshheading:6328312-Epidermal Growth Factor,
pubmed-meshheading:6328312-Gene Amplification,
pubmed-meshheading:6328312-Genes,
pubmed-meshheading:6328312-Humans,
pubmed-meshheading:6328312-Nucleic Acid Hybridization,
pubmed-meshheading:6328312-Peptide Fragments,
pubmed-meshheading:6328312-RNA, Messenger,
pubmed-meshheading:6328312-Receptor, Epidermal Growth Factor,
pubmed-meshheading:6328312-Receptors, Cell Surface
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pubmed:articleTitle |
Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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