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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
21
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pubmed:dateCreated |
1984-7-16
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pubmed:abstractText |
Three experiments demonstrate that inescapable footshock delivered to unrestrained rats produces analgesia as well as performance deficits in subsequent one-way shuttle acquisition. Both the performance and the antinociceptive effects are prevented by pretreatment with as little as 0.1 mg/kg i.p. of the opiate antagonist, naltrexone. These studies suggest that both effects are mediated through opiate receptors with similar underlying naltrexone pharmaco-dynamics.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0024-3205
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2057-66
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6328153-Analgesia,
pubmed-meshheading:6328153-Animals,
pubmed-meshheading:6328153-Avoidance Learning,
pubmed-meshheading:6328153-Electroshock,
pubmed-meshheading:6328153-Male,
pubmed-meshheading:6328153-Naloxone,
pubmed-meshheading:6328153-Naltrexone,
pubmed-meshheading:6328153-Rats,
pubmed-meshheading:6328153-Rats, Inbred Strains,
pubmed-meshheading:6328153-Receptors, Opioid
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pubmed:year |
1984
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pubmed:articleTitle |
Naltrexone prevents footshock-induced performance deficit in rats.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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