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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1984-5-30
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pubmed:abstractText |
Heparin inhibited the dephosphorylation of rabbit skeletal muscle or liver phosphorylase a by protein phosphatase-1. Other glycosaminoglycans (chondroitin sulfates) and their constituents were found to be without effect. The chromatography of a partially purified phosphatase preparation on heparin-Sepharose CL-6B resulted in a fraction that did not bind to the matrix and its activity was not inhibited by heparin or inhibitor-1. The phosphatase bound to heparin-Sepharose was eluted by 0.2 M NaCl and was inhibited by heparin or inhibitor-1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-5793
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
169
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
45-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:6325237-Animals,
pubmed-meshheading:6325237-Carrier Proteins,
pubmed-meshheading:6325237-Chromatography,
pubmed-meshheading:6325237-Glycogen Synthase,
pubmed-meshheading:6325237-Heparin,
pubmed-meshheading:6325237-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:6325237-Liver,
pubmed-meshheading:6325237-Muscles,
pubmed-meshheading:6325237-Phosphoprotein Phosphatases,
pubmed-meshheading:6325237-Phosphorylase a,
pubmed-meshheading:6325237-Protein Phosphatase 1,
pubmed-meshheading:6325237-Proteins,
pubmed-meshheading:6325237-Rabbits
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pubmed:year |
1984
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pubmed:articleTitle |
Heparin inhibits the activity of protein phosphatase-1.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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