Linked Life Data

6325038

Source:http://linkedlifedata.com/resource/pubmed/id/6325038

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1984-6-1
pubmed:abstractText
Activation-dependent changes of mean extracellular calcium concentrations were monitored spectrophotometrically in arterially perfused right ventricle of rabbit via extracellular application of the calcium-sensitive absorption dyes, antipyrylazo III and tetramethylmurexide. After rest periods of 3 minutes or longer, 10% of total dye-accessible calcium (300-500 microM) is depleted cumulatively from the extracellular space by four to eight beats at 2 Hz stimulation. During continued stimulation, or during quiescence following a depletion response, mean extracellular calcium concentrations return toward the prestimulatory level in the course of 2-4 minutes. A single stimulation placed 2-30 seconds subsequent to rapid pacing results in a potentiated beat with an accompanying net increment of mean extracellular calcium. Total dye-accessible calcium can increase by at least 4% at such a beat, and depletion responses can be repeated immediately thereafter. During a sequence of such responses, extracellular calcium lost cumulatively during three to five rapid beats is replenished, for the most part, by a single post-stimulatory beat. These results demonstrate that most of the "activator pool" of cellular calcium can turn over to the extracellular space during a single contraction cycle in rabbit myocardium, and suggest that, in mammalian myocardium, diastolic calcium efflux may be quantitatively negligible in relation to efflux during excitation-contraction coupling.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0009-7330
pubmed:author
pubmed:issnType
Print
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
461-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1984
pubmed:articleTitle
Transsarcolemmal calcium movements in arterially perfused rabbit right ventricle measured with extracellular calcium-sensitive dyes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't