Linked Life Data

6319109

Source:http://linkedlifedata.com/resource/pubmed/id/6319109

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1984-3-6
pubmed:abstractText
The role of a "steriodogenic factor" in the corticoidogenic response to adrenocorticotropic hormone (ACTH) was studied in this experiment. ACTH caused an accumulation of cholesterol within the adrenocortical mitochondria in rat after pretreatment with either cycloheximide (CH) or aminoglutethimide (AG). The cholesterol distribution in these cholesterol-rich mitochondria was examined by measuring the cholesterol concentrations in the outer and inner mitochondrial membranes. In the case of pretreatment with CH, cholesterol was accumulated in the outer membrane and not in the inner membrane. In contrast, in the case of pretreatment with AG, cholesterol was accumulated in the inner membrane and not in the outer membrane. It could be concluded from the presented data that the function of a "steroidogenic factor" in the corticoidogenic response to ACTH might take place at the step of cholesterol translocation from the outer mitochondrial membrane to the inner membrane.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0013-7219
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
335-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
A possible role of "steroidogenic factor" in the corticoidogenic response to ACTH; effect of ACTH, cycloheximide and aminoglutethimide on the content of cholesterol in the outer and inner mitochondrial membrane of rat adrenal cortex.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't