|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1983-12-20
|
|
pubmed:abstractText |
The effect of a naloxone or a dexamethasone pretreatment on the conditioned analgesia resulting from the exposure of rats to an experimental chamber repeatedly paired with a grid shock was investigated. Shock induced disruption of bar pressing activity was taken as a behavioral measure of pain responsiveness. It was found that a 6, but not a 3, mg/kg dose of naloxone i.p. is hyperalgesic in unconditioned rats and effectively antagonizes conditioned analgesia. Dexamethasone (up to a dose of 2 + 1 mg/kg i.p. 23 and 1 h prior) did not alter the pain responsiveness of unconditioned rats, but caused a dose dependent suppression of conditioned analgesia. These results are discussed in terms of an opiate pituitary mechanism subserving conditioned analgesia.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Sep
|
|
pubmed:issn |
0304-3959
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
83-9
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6314229-Adrenocorticotropic Hormone,
pubmed-meshheading:6314229-Animals,
pubmed-meshheading:6314229-Behavior, Animal,
pubmed-meshheading:6314229-Conditioning, Operant,
pubmed-meshheading:6314229-Dexamethasone,
pubmed-meshheading:6314229-Electroshock,
pubmed-meshheading:6314229-Endorphins,
pubmed-meshheading:6314229-Male,
pubmed-meshheading:6314229-Naloxone,
pubmed-meshheading:6314229-Nociceptors,
pubmed-meshheading:6314229-Pituitary Gland,
pubmed-meshheading:6314229-Rats,
pubmed-meshheading:6314229-Rats, Inbred Strains,
pubmed-meshheading:6314229-Receptors, Opioid
|
|
pubmed:year |
1983
|
|
pubmed:articleTitle |
Behavioral evidence for an opiate pituitary mechanism subserving conditioned analgesia.
|
|
pubmed:publicationType |
Journal Article
|
