Linked Life Data

6313329

Source:http://linkedlifedata.com/resource/pubmed/id/6313329

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-12-17
pubmed:abstractText
A metabolically stable GnRH agonist (D-Lys6-GnRH) has been coupled to electron-opaque markers (colloidal gold and ferritin) to characterize the intracellular pathway of the releasing hormone bound by pituitary gonadotropes. This approach has the advantage of increasing the resolution of localization to a "circle of uncertainty" about 10- to 20-fold smaller than that which can be obtained by autoradiography. After an initial uniform distribution on the cell surface, the derivatives were taken up individually as well as in small clusters in coated and uncoated membrane invaginations and moved to the lysosomal compartment either directly or after passage through the Golgi apparatus. The results suggest that labeled GnRH or GnRH-receptor complex may be routed to two distinct intracellular compartments: the lysosome and the Golgi cisternae. It is unclear whether each releasing hormone-marker conjugate must be transported through both compartments before degradation.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1683-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Intracellular pathways of electron-opaque gonadotropin-releasing hormone derivatives bound by cultured gonadotropes.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't