| pubmed-article:6313230 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6313230 | lifeskim:mentions | umls-concept:C0038975 | lld:lifeskim |
| pubmed-article:6313230 | lifeskim:mentions | umls-concept:C1335858 | lld:lifeskim |
| pubmed-article:6313230 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:6313230 | lifeskim:mentions | umls-concept:C0162326 | lld:lifeskim |
| pubmed-article:6313230 | lifeskim:mentions | umls-concept:C1145667 | lld:lifeskim |
| pubmed-article:6313230 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6313230 | pubmed:dateCreated | 1983-12-21 | lld:pubmed |
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| pubmed-article:6313230 | pubmed:abstractText | Fractionation of HeLa cell extracts reveals the presence of a promoter-specific transcription factor, Sp 1, which activates a class of promoters that includes the SV40 early promoter but not several others that have been tested. We analyzed SV40 early-promoter deletion mutants and determined that transcriptional activation by Sp 1 requires sequences within tandem 21 bp repeats located 70-110 bp upstream of the transcription initiation sites. In a DNAase footprinting assay, Sp 1 protected sequences in this same 21 bp repeat region, thus indicating the presence of a specific site for Sp 1 binding. During purification of Sp 1, there was a correlation between transcription-stimulatory activity and promoter-binding activity. These results suggest that direct binding of Sp 1 to sequences in the upstream promoter element is the mechanism by which this factor activates transcription by RNA polymerase II at the SV40 early promoter. | lld:pubmed |
| pubmed-article:6313230 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6313230 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6313230 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6313230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6313230 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6313230 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6313230 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:6313230 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:6313230 | pubmed:author | pubmed-author:TjianRR | lld:pubmed |
| pubmed-article:6313230 | pubmed:author | pubmed-author:DynanW SWS | lld:pubmed |
| pubmed-article:6313230 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6313230 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:6313230 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6313230 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6313230 | pubmed:pagination | 79-87 | lld:pubmed |
| pubmed-article:6313230 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:6313230 | pubmed:meshHeading | pubmed-meshheading:6313230-... | lld:pubmed |
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| pubmed-article:6313230 | pubmed:meshHeading | pubmed-meshheading:6313230-... | lld:pubmed |
| pubmed-article:6313230 | pubmed:meshHeading | pubmed-meshheading:6313230-... | lld:pubmed |
| pubmed-article:6313230 | pubmed:meshHeading | pubmed-meshheading:6313230-... | lld:pubmed |
| pubmed-article:6313230 | pubmed:meshHeading | pubmed-meshheading:6313230-... | lld:pubmed |
| pubmed-article:6313230 | pubmed:meshHeading | pubmed-meshheading:6313230-... | lld:pubmed |
| pubmed-article:6313230 | pubmed:meshHeading | pubmed-meshheading:6313230-... | lld:pubmed |
| pubmed-article:6313230 | pubmed:meshHeading | pubmed-meshheading:6313230-... | lld:pubmed |
| pubmed-article:6313230 | pubmed:meshHeading | pubmed-meshheading:6313230-... | lld:pubmed |
| pubmed-article:6313230 | pubmed:meshHeading | pubmed-meshheading:6313230-... | lld:pubmed |
| pubmed-article:6313230 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6313230 | pubmed:articleTitle | The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter. | lld:pubmed |
| pubmed-article:6313230 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6313230 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:6313230 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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