Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
|
pubmed:dateCreated |
1983-12-17
|
pubmed:abstractText |
The leader RNA transcript of vesicular stomatitis virus (VSV) has been immunoprecipitated from infected BHK cell extracts by anti-La specific sera from patients with systemic lupus erythematosus (SLE). This association was specific as lupus anti-sera with other specificities failed to precipitate leader RNA. The amount of leader RNA associated with the La antigen peaked 4 hr post infection and then declined. Leader RNA complexed with viral nucleocapsid proteins increased at a slower rate but eventually predominated 6 hr post infection. By 16 hr all of the leader RNA was associated with nucleocapsid proteins. Although a significant portion of the leader RNA was present in isolated nuclei 4 hr post infection, all of the leader RNA outside the nucleus was bound to La protein. Leader RNA is the first non-RNA polymerase III product found to associate with the La protein. The proposed function of the leader-La complex in VSV transcription and replication and in viral cytopathology is discussed.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
0092-8674
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
34
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
837-45
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:6313210-Amino Acid Sequence,
pubmed-meshheading:6313210-Animals,
pubmed-meshheading:6313210-Antibodies,
pubmed-meshheading:6313210-Antibody Specificity,
pubmed-meshheading:6313210-Base Sequence,
pubmed-meshheading:6313210-Cricetinae,
pubmed-meshheading:6313210-Cross Reactions,
pubmed-meshheading:6313210-Lupus Erythematosus, Systemic,
pubmed-meshheading:6313210-RNA, Viral,
pubmed-meshheading:6313210-Subcellular Fractions,
pubmed-meshheading:6313210-Vesicular stomatitis Indiana virus,
pubmed-meshheading:6313210-Viral Proteins,
pubmed-meshheading:6313210-Virus Replication
|
pubmed:year |
1983
|
pubmed:articleTitle |
The leader RNA of vesicular stomatitis virus is bound by a cellular protein reactive with anti-La lupus antibodies.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|