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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
|
pubmed:dateCreated |
1983-10-21
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pubmed:abstractText |
Using synaptosomal rat brain membranes, the degradation of Met-enkephalin in both free and receptor-bound form was measured, together with the dissociation of Met-enkephalin from the receptors. The results show that the degradation rate of initially receptor-bound Met-enkephalin is significantly smaller than either the rate of dissociation from the receptors or that of the degradation of free Met-enkephalin. These data suggest that intact Met-enkephalin dissociates from the receptors and then it becomes a target for the same membrane-associated peptidases that split free Met-enkephalin. This view is supported by the good fitness of the measured degradation of initially receptor-bound Met-enkephalin to the predicted degradation curve calculated from the dissociation rate of receptor-bound Met-enkephalin and the degradation rate of free Met-enkephalin.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Aug
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pubmed:issn |
0024-3205
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
29
|
pubmed:volume |
33
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
835-40
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6310302-Animals,
pubmed-meshheading:6310302-Brain,
pubmed-meshheading:6310302-Enkephalin, Methionine,
pubmed-meshheading:6310302-Kinetics,
pubmed-meshheading:6310302-Peptide Hydrolases,
pubmed-meshheading:6310302-Rats,
pubmed-meshheading:6310302-Receptors, Opioid,
pubmed-meshheading:6310302-Synaptic Membranes
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pubmed:year |
1983
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pubmed:articleTitle |
Met-enkephalin binding to opiate receptors is not functionally coupled to biodegradation.
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pubmed:publicationType |
Journal Article,
Comparative Study
|