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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
15
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pubmed:dateCreated |
1983-9-9
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pubmed:abstractText |
We have investigated whether the translocated and the untranslocated human c-myc oncogenes of Burkitt lymphoma cells are equally or differentially expressed in host mouse B cells. The human c-myc mRNA levels in somatic cell hybrids between mouse plasmacytoma cells and Burkitt lymphoma cells with either the t(8;14) or the t(2;8) chromosome translocation were determined by using the nuclease S1 protection procedure. Although both the human parental lines and the hybrid cells carrying the translocated c-muc oncogene expressed high levels of human specific c-myc transcripts, the hybrid cells carrying the untranslocated c-myc gene on normal chromosome 8 did not contain human specific c-myc mRNA. These results suggest that the translocated human c-myc oncogene has escaped the normal transcriptional control to which the untranslocated c-myc gene remains subjected. This interpretation is also supported by the finding that the expression of the c-myc genes of lymphoblastoid cells and of HL-60 promyelocytic leukemia cells are repressed when they are transferred into a mouse plasmacytoma background. The ability of the translocated c-myc oncogene to escape the normal transcriptional control occurring in B cells may be important for the expression of B cell neoplasia in mouse and man. We have also transferred the Burkitt 14q+ chromosome carrying a translocated c-myc oncogene into mouse LM-TK- fibroblasts and studied the levels of human c-myc transcripts in the hybrids. Because the levels of human c-myc transcripts in the fibroblast hybrids are dramatically decreased in comparison to the plasmacytoma hybrids, we conclude that the levels of transcripts of the translocated c-myc oncogene depend on the differentiated state of the cells harboring the translocated chromosome.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-114999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-1172191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-1174504,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-14109133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-271272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-390497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-4107917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-4113130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-4137611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-467575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6188153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6246372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6287464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6289313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6289315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6291150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6298632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6304522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6401867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6402776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6754388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6795508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6806672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6812058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6813863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6818551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6955596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6961453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-6961456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-7260888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-821618,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6308654-946170
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4822-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6308654-Animals,
pubmed-meshheading:6308654-B-Lymphocytes,
pubmed-meshheading:6308654-Burkitt Lymphoma,
pubmed-meshheading:6308654-Cell Line,
pubmed-meshheading:6308654-Cell Transformation, Neoplastic,
pubmed-meshheading:6308654-Clone Cells,
pubmed-meshheading:6308654-DNA Restriction Enzymes,
pubmed-meshheading:6308654-Herpesvirus 4, Human,
pubmed-meshheading:6308654-Humans,
pubmed-meshheading:6308654-Hybrid Cells,
pubmed-meshheading:6308654-Isoenzymes,
pubmed-meshheading:6308654-Leukemia, Lymphoid,
pubmed-meshheading:6308654-Mice,
pubmed-meshheading:6308654-Nucleic Acid Hybridization,
pubmed-meshheading:6308654-Oncogenes,
pubmed-meshheading:6308654-Plasmacytoma,
pubmed-meshheading:6308654-Translocation, Genetic
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pubmed:year |
1983
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pubmed:articleTitle |
Differential expression of the normal and of the translocated human c-myc oncogenes in B cells.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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