Linked Life Data

6302358

Source:http://linkedlifedata.com/resource/pubmed/id/6302358

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-6-10
pubmed:abstractText
Seven healthy volunteers and 3 hospitalized patients were given the same diet for 6 days. The mean intake of cholesterol was 359 mg/day. There was a large difference in the fecal amount of cholesterol and coprostanol among the subjects. The ratio of coprostanol/cholesterol ranged from 0.01 to 4.27. The subjects whose feces contained smaller amount of coprostanol excreted larger amounts of beta-sitosterol and crude fiber, suggesting that the various activities of intestinal flora were lower than the other subjects. The difference in the activity of intestinal flora to convert cholesterol into coprostanol was ascertained by incubating the feces anaerobically with egg yolk in vitro. It was also demonstrated that cholesterol was synthesized de novo and the amount corresponded to 0.1-0.6 g/day. The amounts of sterols in the feces of the other 17 hospitalized patients were also determined and there was an inverse relationship between the serum cholesterol and coprostanol/cholesterol ratio in the feces. These results suggested that the conversion of cholesterol into coprostanol by the intestinal flora might have an important role in the regulation of serum cholesterol level.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-5120
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
14-20
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
Interrelationship between serum and fecal sterols.
pubmed:publicationType
Journal Article, Comparative Study