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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
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pubmed:dateCreated |
1983-3-24
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pubmed:abstractText |
Dopamine-stimulated cyclic AMP accumulation was measured in intact pieces of carp retina following intraocular injections of the dopaminergic neurotoxin 6-hydroxydopamine (6-OHDA). This treatment is known to induce a selective destruction of dopaminergic nerve terminals, and in these experiments caused a 94% reduction in retinal dopamine content. However, dopamine-dependent cyclic AMP accumulation was essentially unaltered in retinas exposed to 6-OHDA, indicating that the dopamine receptors linked to adenylate cyclase in the carp retina are located mainly on postsynaptic elements, and not presynaptically on the dopaminergic terminals.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0006-8993
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
16
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pubmed:volume |
253
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
334-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6295556-Animals,
pubmed-meshheading:6295556-Carps,
pubmed-meshheading:6295556-Cyclic AMP,
pubmed-meshheading:6295556-Dopamine,
pubmed-meshheading:6295556-Hydroxydopamines,
pubmed-meshheading:6295556-Interneurons,
pubmed-meshheading:6295556-Oxidopamine,
pubmed-meshheading:6295556-Retina
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pubmed:year |
1982
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pubmed:articleTitle |
Effects of intraocular injections of 6-hydroxydopamine on dopamine-dependent cyclic AMP accumulation in intact pieces of carp retina.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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