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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1983-1-19
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pubmed:databankReference |
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pubmed:abstractText |
We isolated molecular clones of the provirus-host cell junctions (tumor junction fragments) from two avian leukosis virus-induced lymphomas and compared the structures of these clones with a clone of the normal c-myc gene. Restriction mapping and DNA sequencing demonstrated that normal proviral integration events occurred adjacent to c-myc in both tumors, without gross structural alteration of c-myc. The right long terminal repeat of an avian leukosis virus provirus is integrated upstream from the bulk of the c-myc coding sequences and oriented such that transcription can initiate within the long terminal repeat and proceed downstream into c-myc. A comparison of a tumor junction fragment with the v-myc gene showed that there are two regions of v-myc-related sequences (which are probably exons) separated by 1 kilobase of sequences unrelated to v-myc (probably an intron). A DNA sequence analysis of the tumor junction fragments suggested that integration had occurred in exons adjacent to splice donor sites. This suggests that there are additional exons and introns in c-myc. Based on these findings, a model is proposed for the genesis of the tumor-specific RNAs containing viral-5' and c-myc information in avian leukosis virus-induced lymphomas.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-1054839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-1055375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-158428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-165498,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-199997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-215999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-225569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-226888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-265521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-319344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-322279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-333431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-414220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-455452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-455453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6158786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6159641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6244542,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6245258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6246355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6246368,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6246511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6250038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6251455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6253186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6253899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6254003,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6256079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6258797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6258798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6261142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6262810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6267476,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6267589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6276760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6281465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6281474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-6287213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-7350545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6292482-847462
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
158-66
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6292482-Animals,
pubmed-meshheading:6292482-Avian Leukosis,
pubmed-meshheading:6292482-Avian leukosis virus,
pubmed-meshheading:6292482-Base Sequence,
pubmed-meshheading:6292482-Cell Transformation, Neoplastic,
pubmed-meshheading:6292482-Cell Transformation, Viral,
pubmed-meshheading:6292482-Chickens,
pubmed-meshheading:6292482-Cloning, Molecular,
pubmed-meshheading:6292482-DNA Restriction Enzymes,
pubmed-meshheading:6292482-Genes,
pubmed-meshheading:6292482-Genes, Viral,
pubmed-meshheading:6292482-Lymphoma,
pubmed-meshheading:6292482-Recombination, Genetic,
pubmed-meshheading:6292482-Repetitive Sequences, Nucleic Acid
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pubmed:year |
1982
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pubmed:articleTitle |
Molecular analysis of the c-myc locus in normal tissue and in avian leukosis virus-induced lymphomas.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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