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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1983-1-7
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pubmed:abstractText |
Surface phenotypic markers and the function of lymphocytes in patients affected with the X-linked lymphoproliferative syndrome (XLP) were studied. This syndrome is characterized by a defective response to infection with Epstein Barr virus (EBV). Normal numbers of B and T cells were detected with anti-Ig and monoclonal OKT3 antisera, respectively. T cell subset values, however, were persistently altered: cells reacting with OKT8 were significantly elevated in five of nine patients, accompanied by a slight decrease in the percentage of OKT4-positive cells, leading to abnormally low OKT4 to OKT8 ratios. One patient had a high OKT4 to OKT8 ratio due to low number of OKT8-positive cells. Lymphocytes from patients showed normal proliferation after stimulation with T and B cell mitogens. In contrast, Ig synthesis by lymphocytes after stimulation with B cell mitogens was markedly deficient: low or undetectable levels of one or all classes of Ig were detected, whereas cell lines established from EBV-infected B lymphocytes from patients produced normal quantities of Ig. These studies imply immune regulatory impairments in the patient with XLP.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
129
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2536-40
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6292291-Antibodies, Monoclonal,
pubmed-meshheading:6292291-Antibody Formation,
pubmed-meshheading:6292291-Antigens, Surface,
pubmed-meshheading:6292291-B-Lymphocytes,
pubmed-meshheading:6292291-Cells, Cultured,
pubmed-meshheading:6292291-Female,
pubmed-meshheading:6292291-Herpesvirus 4, Human,
pubmed-meshheading:6292291-Humans,
pubmed-meshheading:6292291-Immunologic Deficiency Syndromes,
pubmed-meshheading:6292291-Lymphocyte Activation,
pubmed-meshheading:6292291-Lymphoproliferative Disorders,
pubmed-meshheading:6292291-Male,
pubmed-meshheading:6292291-Mitogens,
pubmed-meshheading:6292291-T-Lymphocytes,
pubmed-meshheading:6292291-X Chromosome
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pubmed:year |
1982
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pubmed:articleTitle |
Immune deficiency in the X-linked lymphoproliferative syndrome. II. Immunoregulatory T cell defects.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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