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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1982-5-27
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pubmed:abstractText |
DNAs were prepared from twenty-six bacterial species and digested with a variety of restriction endonucleases to determine what modifications the DNAs carry. Several general conclusions could be made: 1) First, in no instance was the DNA of a restriction enzyme. 2) The specificity of the DNA modification was the same as that of its restriction counterpart; there were no cases of the DNAs being modified against a less specific class of restriction enzymes. 3) In most (but not all) cases, the resistance of a bacterium's DNA to its own restriction enzyme could be generalized to include resistance to all other restriction enzymes with the same specificity (isoschizomers). 4) DNA modified within the central tetramer of a recognition sequence is usually protected against cleavage by all related hexameric enzymes possessing that central tetramer. Only three families of DNA presented in this study disobey this rule. 5) Finally, a significant number of cases emerge where bacterial DNA carries a modification but no corresponding restriction endonuclease activity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-1095770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-1097428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-1186657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-166604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-185196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-232555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-236309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-350714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-370402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-377492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-4555406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-4565538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-4576399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-4591672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-4734785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-600794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-6247075,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-6255284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-6255419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-6257650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-6258025,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-6259615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-6262807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-6267988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-6269052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-6269059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-6448253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-712853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6278441-795607
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
11
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
913-34
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1982
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pubmed:articleTitle |
Modification profiles of bacterial genomes.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, Non-P.H.S.
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