Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1981-12-21
pubmed:abstractText
Polymerized actin has been found aggregated into distinctive patches inside transformed cells in culture. The F-actin-specific fluorescent probe, nitrobenzoxadiazole-phallacidin, labels these F-actin aggregates near the ventral cell surface of cells transformed by RNA or DNA tumor viruses, or by chemical mutagens, or spontaneously. Their appearance in all eight transformed cell types studied suggests their ubiquity and involvement in transformation morphology. Actin patches developed in normal rat kidney (NRK) cells transformed by a temperature-sensitive mutant of Rous sarcoma virus (LA23-NRK) within 30 min after a shift from the nonpermissive (39 degrees C) to the permissive temperature (32 degrees C). Patch appearance paralleling viral src gene expression tends to implicate pp60src kinase activity in destabilizing the cytoskeleton. However, appearance of the actin aggregates in cells not transformed by retrovirus calls for alternative mechanisms, perhaps involving an endogenous kinase, for this apparently common trait.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-165499, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-172908, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-174086, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-180536, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-185620, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-186784, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-232735, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-363352, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-4322607, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-4442124, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-4512654, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-6166616, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-6251054, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-6251464, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-6253501, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-6256751, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-6256755, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-6260791, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-6265933, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-6894146, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-6894219, http://linkedlifedata.com/resource/pubmed/commentcorrection/6270163-6928695
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0021-9525
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
797-802
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
F-actin aggregates in transformed cells.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.