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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
1981-10-29
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pubmed:abstractText |
The asialoglycoprotein receptor has been identified on a continuous human hepatoma cell line, HepG2. This receptor requires Ca2+ for ligand binding and is specific for asialoglycoprotein. There are approximately 150,000 ligand molecules bound/cell at 4 degrees C. These receptors represent a homogeneous population of high affinity binding sites with Kd = 7 X 10(-9) M. From the rate of 125I-ASOR binding at 4 degrees C, kon was 0.95 X 10(6) M-1 min-1. Uptake of 125I-ASOR at 37 degrees C was approximately 0.02 pmol/min/10(6) cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9258
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
256
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8878-81
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6267054-Asialoglycoprotein Receptor,
pubmed-meshheading:6267054-Asialoglycoproteins,
pubmed-meshheading:6267054-Binding, Competitive,
pubmed-meshheading:6267054-Carcinoma, Hepatocellular,
pubmed-meshheading:6267054-Cell Line,
pubmed-meshheading:6267054-Humans,
pubmed-meshheading:6267054-Kinetics,
pubmed-meshheading:6267054-Liver Neoplasms,
pubmed-meshheading:6267054-Orosomucoid,
pubmed-meshheading:6267054-Receptors, Cell Surface
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pubmed:year |
1981
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pubmed:articleTitle |
Characterization of the asialoglycoprotein receptor in a continuous hepatoma line.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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