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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
1981-7-23
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pubmed:abstractText |
Lymphocyte proliferative responses to mitogens and herpes virus antigens are diminished during cytomegalovirus (CMV) mononucleosis. We analyzed peripheral blood T lymphocytes from patients in the acute and convalescent phases of CMV mononucleosis using monoclonal antibodies directed against the T helper and the T cytotoxic-suppressor cell subsets. Acute CMV infection is associated with a reversal in the normal ratio of helper to suppressor T lymphocytes with relative and absolute decreases in T helper cells and corresponding increases in T suppressor cells. These alterations in T lymphocyte subsets are accompanied by diminished lymphocyte responses to the mitogen concanavalin A (Con A). During convalescence, helper T lymphocytes increase, suppressor T lymphocytes decrease, and Con A responses return to normal.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
126
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2114-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6262407-Acute Disease,
pubmed-meshheading:6262407-Adult,
pubmed-meshheading:6262407-Aged,
pubmed-meshheading:6262407-Convalescence,
pubmed-meshheading:6262407-Cytomegalovirus,
pubmed-meshheading:6262407-Female,
pubmed-meshheading:6262407-Freezing,
pubmed-meshheading:6262407-Humans,
pubmed-meshheading:6262407-Infectious Mononucleosis,
pubmed-meshheading:6262407-Lymphocyte Activation,
pubmed-meshheading:6262407-Male,
pubmed-meshheading:6262407-Middle Aged,
pubmed-meshheading:6262407-T-Lymphocytes
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pubmed:year |
1981
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pubmed:articleTitle |
Analysis of T lymphocyte subsets in cytomegalovirus mononucleosis.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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