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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5806
|
pubmed:dateCreated |
1981-6-13
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pubmed:abstractText |
Analyses of DNA and RNA from avian leukosis virus (ALV)-induced lymphomas have provided strong evidence that, in most tumours, ALV induces neoplastic disease by activating the c-myc gene, the cellular counterpart of the transforming gene of MC29 virus. The data indicate that, as a rare event, the ALV provirus integrates adjacent to the c-myc gene and that transcription, initiating from a viral promoter, causes enhanced expression of c-myc, leading to neoplastic transformation.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0028-0836
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
9
|
pubmed:volume |
290
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
475-80
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:6261142-Avian leukosis virus,
pubmed-meshheading:6261142-Base Sequence,
pubmed-meshheading:6261142-Cell Transformation, Viral,
pubmed-meshheading:6261142-DNA, Viral,
pubmed-meshheading:6261142-Genes,
pubmed-meshheading:6261142-Genetic Linkage,
pubmed-meshheading:6261142-Lymphoma,
pubmed-meshheading:6261142-Operon,
pubmed-meshheading:6261142-RNA, Neoplasm,
pubmed-meshheading:6261142-RNA, Viral,
pubmed-meshheading:6261142-Transcription, Genetic
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pubmed:year |
1981
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pubmed:articleTitle |
Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|