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pubmed-article:6260841pubmed:abstractTextProgesterone appears to be the physiological inducer of meiosis in amphibian oocytes. In Rana pipiens, dl-propranolol mimics the action of progesterone and both agents have a common action in producing a rapid [45Ca] efflux and a fall in intracellular cAMP followed by nuclear breakdown. Comparison of the rate of hydrolysis of injected [3H]-cAMP and of the conversion of injected [3H]-ATP to [3H]-cAMP followed exposure to meiotic inducers and inhibitors indicates that adenylate cyclase and not phosphodiesterase is the rate-limiting step in regulating [cAMP]i in the oocyte. The results suggest that progesterone initiates the resumption of the meiotic divisions by down-regulation of membrane adenylate cyclase, possibly via Ca2+ release from specific membrane sites.lld:pubmed
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pubmed-article:6260841pubmed:articleTitleRegulation of Ca2+ and cyclic AMP during the first meiotic division in amphibian oocytes by progesterone.lld:pubmed
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