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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1981-5-26
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pubmed:abstractText |
In the presence of 10(-9) M calcium, rod outer segments freshly detached from dark-adapted frog retinas contain between 0.01 and 0.02 moles of guanosine 3',5'-cyclic monophosphate (cyclic GMP) per mole of rhodopsin. The dark level of cyclic GMP is reduced approximately 50% by illumination that bleaches 5 x 10(5) rhodopsin molecules/outer segments. The dark levels of cyclic GMP also can be suppressed to approximately 0.007 mol/mol of rhodopsin by increasing the concentration of calcium from 10(-9) M to 2 x 10(-9) M, and they remain at this level as calcium concentration is raised to 10(-3) M. The final level to which illumination reduces cyclic GMP in unaffected by the calcium concentration between 10(-9) and 10(-3) M. The maximal light-induced decrease in cyclic GMP occurs within 1 s from the onset of illumination at all calcium concentrations. The magnitude and time-course of the light-induced decrease in cyclic GMP measured in these experiments are comparable to values obtained previously (Woodruff et al. 1977. J. Gen. Physiol. 69:677-679; Woodruff and Bownds. 1979. J. Gen. Physiol. 73:629-653). The data are consistent with a role for cyclic GMP in visual transduction irrespective of the calcium concentration.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-112242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-181525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-188039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-194013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-207816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-214434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-222877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-224596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-225407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-231925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-4255372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-4334220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-4334492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-4359063,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-4369896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-6247421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-6255064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6259273-825637
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0022-1295
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1981
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pubmed:articleTitle |
Influence of calcium on guanosine 3',5'-cyclic monophosphate levels in frog rod outer segments.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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